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Updated: Sep 24, 2025

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
Concise total syntheses of phelligridins A, C, and D
Takayuki Ohyoshi1, Keisuke Mitsugi1, Tatsuya Higuma1
1Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba 1-1-1 Tennodai Tsukuba 305-8571 Japan kigoshi@chem.tsukuba.ac.jp ohyoshi@chem.tsukuba.ac.jp.
Abstract:
We have established a concise and scalable synthetic pathway for phelligridins A (1), C (2) and D (3). The synthetic highlights were Suzuki-Miyaura coupling and aldol-type condensation of α-pyrone. Phelligridin A was synthesized in four steps, while phelligridins C and D were each synthesized in six steps. Furthermore, we have revealed that the whole structure is essential for the cytotoxicity of phelligridins.
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