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Published on: July 19, 2021
Cytotoxic metabolites from the endophytic fungus Chaetomium globosum 7951
Fang Wang1,2, Wuli Zhao2, Conghui Zhang2
1School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University Shenyang 110016 China zhangyxzsh@163.com.
Abstract:
The following compounds were isolated from acetate extracts of Chaetomium globosum 7951 solid cultures: demethylchaetocochin C (1) and chaetoperazine A (3), two new epipolythiodioxopiperazine (ETP) alkaloids, a novel pyridine benzamide, 4-formyl-N-(3'-hydroxypyridin-2'-yl) benzamide (6), and three known ETP derivatives (2, 4, and 5). The structures of these compounds were determined using extensive spectroscopic data analysis. Compounds 1-3, and 6, inhibited the growth of MCF-7, MDA-MB-231, H460 and HCT-8 cells with an IC50 of 4.5 to 65.0 μM.
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