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Updated: Sep 24, 2025

Synthesis of Hypervalent Iodonium Alkynyl Triflates for the Application of Generating Cyanocarbenes
Published on: September 8, 2013
SO2F2-Mediated one-pot cascade process for transformation of aldehydes (RCHO) to cyanamides (RNHCN)
Yiyong Zhao1, Junjie Wei2, Shuting Ge1
1College of Chemical Engineering, Zhejiang University of Technology Hangzhou 310014 People's Republic of China gfzhang@zjut.edu.cn dingcr@zjut.edu.cn.
Abstract:
A simple, mild and practical cascade process for the direct conversion of aldehydes to cyanamides was developed featuring a wide substrate scope and great functional group tolerability. This method allows for transformations of readily available, inexpensive, and abundant aldehydes to highly valuable cyanamides in a pot, atom, and step-economical manner with a green nitrogen source. This protocol will serve as a robust tool for the installation of the cyanamide moiety in various complicated molecules.
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