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Quantitative Susceptibility Mapping: Basic Methods and Clinical Applications
Taisuke Harada1, Kohsuke Kudo1, Noriyuki Fujima1
1From the Department of Diagnostic Imaging, Hokkaido University Graduate School of Medicine, N15 W7, Kita-ku, Sapporo, Japan (T.H., K.K., M.Y.); Center for Cause of Death Investigation (T.H.) and Global Center for Biomedical Science and Engineering (K.K.), Faculty of Medicine, Hokkaido University, Sapporo, Japan; Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan (T.H., K.K., N.F., M.Y., Y.I.); Innovative Technology Laboratory, Fujifilm Healthcare Corporation, Tokyo, Japan (R.S., T.S.); Fujifilm Healthcare Corporation, Chiba, Japan (Y.B.); Division of Ultrahigh Field MRI, Institute for Biomedical Sciences, Iwate Medical University, Yahaba, Japan (I.U.); and Department of Functional Brain Imaging, Institute for Quantum Medical Science, Quantum Life and Medical Science Directorate, National Institutes for Quantum Science and Technology, Chiba, Japan (M.M.).
Abstract:
Quantitative susceptibility mapping (QSM), one of the advanced MRI techniques for evaluating magnetic susceptibility, offers precise quantitative measurements of spatial distributions of magnetic susceptibility. Magnetic susceptibility describes the magnetizability of a material to an applied magnetic field and is a substance-specific value. Recently, QSM has been widely used to estimate various levels of substances in the brain, including iron, hemosiderin, and deoxyhemoglobin (paramagnetism), as well as calcification (diamagnetism). By visualizing iron distribution in the brain, it is possible to identify anatomic structures that are not evident on conventional images and to evaluate various neurodegenerative diseases. It has been challenging to apply QSM in areas outside the brain because of motion artifacts from respiration and heartbeats, as well as the presence of fat, which has a different frequency to the proton. In this review, the authors provide a brief overview of the theoretical background and analyze methods of converting MRI phase images to QSM. Moreover, we provide an overview of the current clinical applications of QSM. Online supplemental material is available for this article. ©RSNA, 2022.
