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Can pattern electroretinography be a relevant diagnostic aid in amblyopia? - A systematic review
Andresa Fernandes1,2,3, Nuno Pinto1,2,3, Ana Rita Tuna1,2,3
1Faculty of Health Sciences, University of Beira Interior, Covilhã, Portugal.
Seminars in Ophthalmology
|May 6, 2022
Summary
Pattern Electroretinography (PERG) may help diagnose amblyopia by detecting functional impairments. This review found consistent decreases in PERG amplitude and delayed latency in amblyopic eyes, suggesting retinal changes.
Area of Science:
- Ophthalmology
- Neuroscience
- Physiology
Background:
- Amblyopia, often considered a cortical visual imbalance, may involve retinal changes.
- Pattern Electroretinography (PERG) is a sensitive electrophysiological method for assessing macular function.
Purpose of the Study:
- To systematically review scientific literature for consistent changes in PERG responses of amblyopic eyes.
Main Methods:
- Searches of PubMed and Embase databases were conducted.
- Keywords included "Electroretinography", "Amblyopia", "Pattern Electroretinography", and "PERG".
- PERG P50-N95 amplitude and P50 latency were analyzed.
Main Results:
- Six articles were included from 234 initially found.
- Most studies focused on children.
- Consistent findings showed decreased P50-N95 amplitude and/or delayed P50 latency in amblyopic eyes compared to normal eyes.
Conclusions:
- PERG shows potential as a diagnostic aid for amblyopia.
- The technique may detect functional impairment in amblyopic eyes.
