Biomanufacturing human tissues via organ building blocks

Area of Science:

• Biomedical Engineering
• Regenerative Medicine
• Tissue Engineering

Background:

• The critical shortage of organ donors necessitates innovative solutions for organ replacement.
• Engineering complex human tissues that mimic native organ structure and function remains a significant challenge.

Purpose of the Study:

• To review the use of organ building blocks (OBBs) for constructing functional human tissues and organs.
• To highlight the potential of OBBs in addressing the organ donor shortage through therapeutic repair and replacement.

Main Methods:

• Review of differentiation and maturation protocols for OBBs, including spheroids, organoids, and assembloids.
• Analysis of 3D assembly strategies for OBBs to achieve desired cellular-to-tissue-level organization.

Main Results:

• OBBs provide a viable pathway for engineering organ-specific tissues with controlled organization.
• The integration of OBBs facilitates the creation of functional human tissues for potential therapeutic use.

Conclusions:

• Organ building blocks represent a promising approach for on-demand human organ construction.
• Further research into OBBs will unlock new opportunities in regenerative medicine and organ transplantation.