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Updated: Sep 14, 2026

Unraveling the Unseen Players in the Ocean - A Field Guide to Water Chemistry and Marine Microbiology
Published on: November 5, 2014
Isolation of Water-Soluble Metabolites from Marine Invertebrates and Microorganisms
Lamonielli F Michaliski1, Darlon I Bernardi1, Roberto G S Berlinck2
1Instituto de Química de São Carlos, Universidade de São Paulo, São Carlos, SP, Brazil.
Abstract:
The isolation of pure organic compounds from biological sources, reaction media, or other complex molecular matrixes is the first step to overcome before further biological and chemical investigations. While the isolation of chemicals soluble in organic solvents is commonly accomplished, the isolation of water-soluble organic compounds is less often addressed. We present here a simple method for the isolation of water-soluble organic compounds, using adsorptive macroporous resins and reversed-phase chromatography.
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