Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

2.6K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
2.6K
Stem Cell Niche01:26

Stem Cell Niche

5.3K
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
5.3K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.3K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.3K
Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

3.8K
A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
3.8K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.7K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.7K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

3.3K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Distinct allergen-specific T cell receptor clonotypes drive divergent immune programs in a cloned mouse model of atopic dermatitis.

Allergology international : official journal of the Japanese Society of Allergology·2026
Same author

Pustular Mycosis Fungoides Triggered by Systemic Interferon-γ.

The Journal of dermatology·2026
Same author

Ocular Manifestations Leading to the Diagnosis of Pseudoxanthoma Elasticum with a Novel Heterozygous ABCC6 Mutation: A Case Report.

Case reports in dermatology·2026
Same author

Complications and Laboratory Test Findings Among Patients With Generalized Pustular Psoriasis: A Retrospective Chart Review Study.

Experimental dermatology·2026
Same author

Three-Year Follow-Up of the PACI Randomized Controlled Trial (PACI-ON): Effects of Early Intervention for Atopic Dermatitis on Atopic March.

Allergy·2026
Same author

IL-17A-Exposed Senescent Fibroblasts Evade Apoptosis and Clearance.

Experimental dermatology·2026

Related Experiment Video

Updated: Sep 24, 2025

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
10:05

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

Published on: May 8, 2020

2.0K

Age-related decrease in responsiveness of CD271-positive skin stem cells to growth factors.

Hirohiko Akamatsu1, Takaaki Yamada1,2,3, Ayumi Sanada2

  • 1Department of Applied Cell and Regenerative Medicine, Fujita Health University School of Medicine, Toyoake, Japan.

Experimental Dermatology
|May 7, 2022
PubMed
Summary

Skin stem cell responsiveness to growth factors declines with age, impacting skin repair and healing. Suppressing decreased receptor expression may maintain skin function.

Keywords:
agningegfrfgfrstem cell

More Related Videos

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
13:59

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

8.3K
Generation and Culturing of Primary Human Keratinocytes from Adult Skin
10:42

Generation and Culturing of Primary Human Keratinocytes from Adult Skin

Published on: December 22, 2017

16.6K

Related Experiment Videos

Last Updated: Sep 24, 2025

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
10:05

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

Published on: May 8, 2020

2.0K
A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
13:59

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

8.3K
Generation and Culturing of Primary Human Keratinocytes from Adult Skin
10:42

Generation and Culturing of Primary Human Keratinocytes from Adult Skin

Published on: December 22, 2017

16.6K

Area of Science:

  • Dermatology
  • Aging Research
  • Stem Cell Biology

Background:

  • Skin stem cell numbers decrease with age, affecting homeostasis and wound healing.
  • Age-related functional decline in stem cells contributes to impaired skin regeneration.
  • Epidermal growth factor/receptor (EGF/EGFR) and fibroblast growth factor-2/receptor (FGF2/FGFR) signaling are crucial for skin repair.

Purpose of the Study:

  • To investigate age-related changes in EGF/EGFR and FGF2/FGFR signaling in skin stem cells.
  • To analyze the impact of aging on the responsiveness of interfolliclicular epidermal stem cells (IFE-SCs) and dermal stem cells (DSCs) to growth factors.

Main Methods:

  • Immunohistological analysis of EGFR and FGFR1 expression in skin samples from different age groups.
  • Isolation and functional assessment of IFE-SCs and DSCs from elderly subjects.
  • Evaluation of stem cell responsiveness to EGF and FGF2 in vitro.

Main Results:

  • Aged skin showed decreased expression of EGFR in IFE-SCs and FGFR1 in DSCs.
  • IFE-SCs and DSCs from elderly subjects displayed reduced responsiveness to EGF and FGF2, respectively.
  • Lowered growth factor signaling correlates with age-related decline in skin regenerative functions.

Conclusions:

  • Reduced responsiveness of skin stem cells to growth factors is a key factor in age-related skin deterioration.
  • Targeting EGFR and FGFR1 expression may offer a strategy to maintain skin homeostasis and improve wound healing in aging individuals.