Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tri-calcium phosphate as a bone substitute.

B V Rejda, J G Peelen, K de Groot

    Journal of Bioengineering
    |January 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Diagnosis and treatment of ANCA-associated vasculitis : S3 guideline of the German Society for Rheumatology and Clinical Immunology e. V. (DGRh) and German Society for Internal Medicine e. V. (DGIM), German Society for Nephrology e. V. (DGfN), German Society for ENT Medicine and Head and Neck Surgery e. V. (DGHNO-KHC), German Ophthalmological Society e. V. (DOG), German Society for Neurology e. V. (DGN), German Society for Pneumology and Respiratory Medicine e. V. (DGP), German Society for Pathology e. V. (DGP), German Radiological Society, Society for Medical Radiology e. V. (DRG), Federal Association of German Pathologists, Federal Kidney Association e. V., German Rheumatism League Federal Association e. V.]

    Zeitschrift fur Rheumatologie·2025
    Same author

    [Diagnosis and treatment of ANCA-associated vasculitis : SHORT VERSION of the S3 guideline of the German Society for Rheumatology and Clinical Immunology e. V. (DGRh) and German Society for Internal Medicine e. V. (DGIM), German Society for Nephrology e. V. (DGfN), German Society for Otorhinolaryngology and Head and Neck Surgery e. V. (DGHNO-KHC), German Ophthalmological Society e. V. (DOG), German Society for Neurology e. V. (DGN), German Society for Pneumology and Respiratory Medicine e. V. (DGP), German Society for Pathology e. V. (DGP), German Radiological Society, Society for Medical Radiology e. V. (DRG), Federal Association of German Pathologists, Federal Kidney Association e. V., German Rheumatism League Federal Association e. V.]

    Zeitschrift fur Rheumatologie·2025
    Same author

    Sulfasalazine-induced mononucleosis-like-illness and haemolysis.

    Scandinavian journal of rheumatology·2020
    Same author

    [Lupus nephritis].

    Der Internist·2019
    Same author

    Comparability of patients with ANCA-associated vasculitis enrolled in clinical trials or in observational cohorts.

    Clinical and experimental rheumatology·2015
    Same author

    [Rheumatism and kidney].

    Zeitschrift fur Rheumatologie·2015
    Same journal

    An accurate data collection method for spatial motion using a sonic digitizer.

    Journal of bioengineering·1978
    Same journal

    A model for evaluating the ocular contusion injury potential of propelled objects.

    Journal of bioengineering·1978
    Same journal

    The wear behavior of vacuum-vapor-deposited carbon films.

    Journal of bioengineering·1978
    Same journal

    Tissue ingrowth in porous acrylic cement.

    Journal of bioengineering·1978
    Same journal

    In vitro cytotoxicity and in vivo acute responses to some amino acid copolymers and their esters.

    Journal of bioengineering·1978
    Same journal

    The thrombogenicity of radiation grafted polymers as measured by the vena cava ring test.

    Journal of bioengineering·1978
    See all related articles

    Strong porous tri-calcium phosphate ceramic shows promise as a bone implant material. It biodegrades via osteoclastic activity, with bone mineral depositing directly onto its surface.

    Area of Science:

    • Biomaterials Science
    • Orthopedic Research
    • Ceramic Engineering

    Background:

    • Bone defects and injuries necessitate effective bone graft substitutes.
    • Bioceramics offer potential for bone regeneration due to their biocompatibility.
    • Tri-calcium phosphate (TCP) is a well-studied biomaterial for bone applications.

    Purpose of the Study:

    • To fabricate and evaluate a strong, porous tri-calcium phosphate (TCP) ceramic for bone implantation.
    • To assess the in vivo biological response to the novel TCP ceramic.
    • To investigate the degradation mechanism and bone integration of the ceramic.

    Main Methods:

    • Fabrication of a strong, porous tri-calcium phosphate ceramic.
    • In vivo implantation studies to evaluate biocompatibility and host response.

    Related Experiment Videos

  • Histological analysis to assess tissue integration and biodegradation.

    • Main Results:

    • The fabricated TCP ceramic demonstrated good mechanical strength and porosity.
    • No adverse foreign body reactions were observed post-implantation.
    • Osteoclastic activity was identified as the primary mechanism for ceramic biodegradation.
    • Direct deposition of new bone mineral onto the ceramic surface was evident.

    Conclusions:

    • Strong, porous tri-calcium phosphate ceramic is a viable candidate for bone implant applications.
    • The material elicits a positive biological response, promoting bone integration.
    • Osteoclastic resorption facilitates the degradation and replacement of the ceramic with new bone.