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Related Concept Videos

Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

233
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
233
Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

230
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
230
REM Sleep Behavior Disorder01:15

REM Sleep Behavior Disorder

439
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
439
Understanding Sleep01:11

Understanding Sleep

693
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
693

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Related Experiment Video

Updated: Sep 24, 2025

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
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Abnormal dynamic functional connectivity after sleep deprivation from temporal variability perspective.

Jinbo Sun1,2, Rui Zhao3, Zhaoyang He3

  • 1Engineering Research Center of Molecular and Neuro Imaging of the Ministry of Education, School of Life Sciences and Technology, Xidian University, Xi'an, China.

Human Brain Mapping
|May 7, 2022
PubMed
Summary
This summary is machine-generated.

Sleep deprivation (SD) alters brain function by changing temporal variability in key networks. These findings offer new insights into the neural basis of sleep loss and related disorders.

Keywords:
dynamic functional connectivitypsychomotor vigilance testresting-state functional magnetic resonance imagingsleep deprivationtemporal variability

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Area of Science:

  • Neuroscience
  • Cognitive Science
  • Medical Imaging

Background:

  • Sleep deprivation (SD) is prevalent and linked to various clinical disorders.
  • Previous research used static and dynamic MRI to study SD's neural mechanisms.
  • Recent studies emphasize dynamic functional brain organization during resting-state scans.

Purpose of the Study:

  • To investigate the impact of SD on dynamic functional brain connectivity using temporal variability.
  • To examine changes in regional and network-level temporal variability after SD.
  • To correlate functional connectivity changes with cognitive performance after SD.

Main Methods:

  • Utilized a novel temporal variability metric on resting-state fMRI data from 55 healthy young adults.
  • Analyzed regional-level temporal variability in large-scale brain regions and thalamus subregions.
  • Assessed intra-network and inter-network temporal variability, including the default mode network (DMN) and visual network.
  • Correlated functional connectivity with psychomotor vigilance test (PVT) performance.

Main Results:

  • Sleep-deprived subjects exhibited increased temporal variability in widespread brain regions and decreased variability in thalamus subregions.
  • Enhanced intra-network temporal variability was observed in the DMN.
  • Increased inter-network temporal variability was found between numerous subnetwork pairs.
  • A negative correlation was identified between DMN-visual network temporal variability and slowest PVT response speed after SD.

Conclusions:

  • Sleep deprivation leads to abnormal dynamic functional brain configuration.
  • These findings provide novel insights into the neural underpinnings of sleep deprivation.
  • The study contributes to understanding the pathophysiology of clinical disorders associated with SD.