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Solid lipid microspheres decorated nanoparticles as drug carriers.

Victoria Nahum1, Abraham J Domb1

  • 1Institute of Drug Research, School of Pharmacy-Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel.

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Summary

Researchers developed novel Solid Pickering microparticles using beeswax and nanoparticles. These surfactant-free carriers encapsulate active agents, offering slow release for applications in food, medicine, and personal care.

Keywords:
Controlled releasePolysaccharide nanoparticlesSolid lipidSolid lipid microparticlesSolid pickering particles

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Area of Science:

  • Materials Science
  • Colloid and Surface Chemistry

Background:

  • Pickering emulsions, known since 1906, involve nanoparticles stabilizing oil droplets in aqueous media.
  • No prior reports exist on solid lipid microparticles decorated with nanoparticles.

Purpose of the Study:

  • To develop and characterize novel surfactant-free, nanoparticle-decorated solid lipid microparticles.
  • To evaluate their potential as carriers for active agents with extended release.

Main Methods:

  • Dispersing molten beeswax in hot aqueous media containing chitosan and starch nanoparticles.
  • Cooling the dispersion to solidify the lipid and form spherical microparticles.
  • Encapsulating model poorly water-soluble drugs (Ibuprofen, Lidocaine) for release studies.

Main Results:

  • Successfully fabricated Solid Pickering microparticles composed of beeswax and surface-embedded chitosan/starch nanoparticles.
  • Demonstrated encapsulation of active agents within a solid lipid core.
  • Achieved an extended release profile for encapsulated drugs, lasting at least one week.

Conclusions:

  • Solid Pickering microparticles represent a novel, surfactant-free carrier system.
  • The system offers potential for controlled, long-term release of active agents.
  • Applications are foreseen in diverse fields including food, medicine, agriculture, and personal care products.