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Updated: Sep 24, 2025
Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
Published on: October 7, 2011
[Functional analysis of host factors involved in mumps virus propagation]
1Department of Virology III, National Institute of Infectious Diseases.
Abstract:
Mumps virus (MuV) is the causative agent of mumps, a common childhood illness characterized by fever and swelling of the salivary glands. Like other viral infections, a number of host proteins are thought to involve in MuV infection. We have shown the function of several host factors in MuV infection. The chaperone proteins, heat shock protein 70 (Hsp70) and Hsp90, interact with the P and L proteins that form the polymerase complex and function in the protein quality control of these viral proteins, and thus they are essential host factors in MuV RNA synthesis. The R2TP complex is a host factor that contributes to effective viral propagation by precise regulation of viral RNA synthesis and evasion of host immune responses, and Rab11 is a host factor involved in viral RNP trafficking to the plasma membrane. This article summarizes the functions of host factors involved in MuV infection based on our researches.
Insights
This study details how host proteins like Hsp70, Hsp90, the R2TP complex, and Rab11 are crucial for mumps virus (MuV) replication and spread. These factors regulate viral RNA synthesis, protein quality, and transport.
Area of Science:
- Virology
- Molecular Biology
- Immunology
Background:
- Mumps virus (MuV) causes mumps, a common childhood illness.
- Host proteins play critical roles in viral infections, including MuV.
Purpose of the Study:
- To summarize the functions of host factors involved in MuV infection.
- To highlight the essential roles of specific host proteins in the MuV life cycle.
Main Methods:
- The study focuses on research findings regarding host-pathogen interactions.
- Specific host factors investigated include chaperone proteins (Hsp70, Hsp90), the R2TP complex, and Rab11.
Main Results:
- Heat shock proteins 70 (Hsp70) and 90 (Hsp90) interact with MuV polymerase proteins (P and L), aiding in protein quality control and essential for viral RNA synthesis.
- The R2TP complex regulates viral RNA synthesis and helps MuV evade host immune responses.
- Rab11 facilitates the trafficking of viral ribonucleoproteins (RNPs) to the plasma membrane.
Conclusions:
- Host factors are indispensable for efficient mumps virus replication and propagation.
- Targeting these host factors could offer novel strategies for antiviral therapies against mumps.
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