Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Kikuchi-Fujimoto Disease Presenting With Complex Neurological Manifestations: A Case Report.

Case reports in neurological medicine·2026

Same author

A Comparative Analysis of Carboplatin- and Cisplatin-Based Concurrent Chemoradiation for Treating Locally Advanced Cervical Cancer: A Single-Center Observational Study.

Cureus·2026

Same author

When the Pediatric Gut Stops: The Pattern of Intestinal Obstruction in Children.

Cureus·2026

Same author

Role of Free-Flow Uroflowmetry as an Adjunct in Management of Urinary Tract Dysfunction for Children "At-Risk" for Neurogenic Bladder.

Lower urinary tract symptoms·2026

Same author

Comparative evaluation of first molar odontometry and mandibular measurements technique for gender determination.

Bioinformation·2026

Same author

Whole exome sequencing of lung cancer in Indian patients reveals driver genes and novel mutations with therapeutic potential.

Indian journal of surgical oncology·2026

Same journal

Immune checkpoint inhibitors in advanced cholangiocarcinoma: a systematic review of efficacy, safety, and emerging biomarkers.

Journal of the Egyptian National Cancer Institute·2026

Same journal

Silver-loaded nanoemulsion of Nepeta glomerulosa extract enhances cytotoxicity and induces apoptosis in A549 and AGS cancer cells.

Journal of the Egyptian National Cancer Institute·2026

Same journal

Bidirectional mendelian randomization identifies plasma proteins associated with cervical cancer risk.

Journal of the Egyptian National Cancer Institute·2026

Same journal

Decoding the functional landscape of long non-coding RNAs in hepatocellular carcinoma: molecular mechanisms, clinical implications, and therapeutic prospects.

Journal of the Egyptian National Cancer Institute·2026

Same journal

Navigating toxicity in lung cancer immunotherapy: challenges and advances in Nano medicine drug delivery.

Journal of the Egyptian National Cancer Institute·2026

Same journal

Microbiome and cancer immunotherapy: a bibliometric analysis.

Journal of the Egyptian National Cancer Institute·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Sep 24, 2025

Preparation of Primary Acute Lymphoblastic Leukemia Cells in Different Cell Cycle Phases by Centrifugal Elutriation

Preparation of Primary Acute Lymphoblastic Leukemia Cells in Different Cell Cycle Phases by Centrifugal Elutriation

Published on: November 10, 2017

Pre-phase strategy to mitigate first cycle effect in diffuse large B cell lymphoma.

A H Rudresha¹, Syed Adil Hassan¹, A Sreevalli¹

¹Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Dr. M H Marigowda Rd., Hombegowda Nagar, Bengaluru, Karnataka, 560029, India.

Journal of the Egyptian National Cancer Institute

|May 8, 2022

Summary

This summary is machine-generated.

Pre-phase treatment with vincristine and prednisolone significantly improves performance status and reduces febrile neutropenia in diffuse large B cell lymphoma (DLBCL) patients. This approach alleviates early treatment toxicities, enhancing patient outcomes.

Keywords:

DLBCL First cycle effect Pre-phase

More Related Videos

Directed Differentiation of Induced Pluripotent Stem Cells towards T Lymphocytes

Directed Differentiation of Induced Pluripotent Stem Cells towards T Lymphocytes

Published on: May 14, 2012

A Syngeneic Mouse B-Cell Lymphoma Model for Pre-Clinical Evaluation of CD19 CAR T Cells

A Syngeneic Mouse B-Cell Lymphoma Model for Pre-Clinical Evaluation of CD19 CAR T Cells

Published on: October 16, 2018

Related Experiment Videos

Last Updated: Sep 24, 2025

Preparation of Primary Acute Lymphoblastic Leukemia Cells in Different Cell Cycle Phases by Centrifugal Elutriation

Preparation of Primary Acute Lymphoblastic Leukemia Cells in Different Cell Cycle Phases by Centrifugal Elutriation

Published on: November 10, 2017

Directed Differentiation of Induced Pluripotent Stem Cells towards T Lymphocytes

Directed Differentiation of Induced Pluripotent Stem Cells towards T Lymphocytes

Published on: May 14, 2012

A Syngeneic Mouse B-Cell Lymphoma Model for Pre-Clinical Evaluation of CD19 CAR T Cells

A Syngeneic Mouse B-Cell Lymphoma Model for Pre-Clinical Evaluation of CD19 CAR T Cells

Published on: October 16, 2018

Area of Science:

Hematology
Oncology
Clinical Trials

Background:

Diffuse large B cell lymphoma (DLBCL) patients experience high treatment-related toxicities, particularly during the initial treatment phase (first cycle effect).
Previous non-randomized studies suggested pre-phase treatment could mitigate these early side-effects.

Purpose of the Study:

To prospectively validate the efficacy of pre-phase treatment in newly diagnosed DLBCL patients.
To assess the impact of pre-phase therapy on patient performance status and neutropenia rates.

Main Methods:

A single-arm prospective study enrolled 180 newly diagnosed DLBCL patients aged over 18.
Patients received 7 days of vincristine and prednisolone pre-phase treatment before initiating definitive chemotherapy.
Follow-up included assessment of clinical variables and toxicity for 30 days post-first chemotherapy cycle.

Main Results:

Significant improvement in Eastern Cooperative Oncology Group (ECOG) performance status was observed, with 38.4% of patients achieving ECOG 0 post-pre-phase therapy (p < 0.001).
Febrile neutropenia incidence was markedly reduced to 12.8% compared to a historical cohort (34%).

Conclusions:

Pre-phase therapy with vincristine and prednisolone is an effective strategy to improve performance status in DLBCL patients.
This regimen significantly diminishes the incidence of neutropenia, thereby reducing early treatment-related toxicities.