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[Association between functional dyspepsia and serum levels of brain-gut peptides in children]
Dong-Wei Wang1, Xiao-Lin Ye, Jie Wu1
1Department of Pediatric Gastroenterology, Shengjing Hospital, China Medical University, Shenyang 110004, China.
Insights
Children with functional dyspepsia (FD) show elevated serum levels of calcitonin gene-related peptide (CGRP) and nesfatin-1. These peptides correlate with specific FD symptoms, suggesting their role in the condition.
Area of Science:
- Pediatric Gastroenterology
- Neurogastroenterology
- Biochemistry
Background:
- Functional dyspepsia (FD) is a common gastrointestinal disorder in children.
- Brain-gut peptides play a crucial role in regulating gastrointestinal function.
- Understanding the role of specific peptides in pediatric FD is important for diagnosis and treatment.
Purpose of the Study:
- To investigate the association between functional dyspepsia (FD) in children and serum levels of brain-gut peptides.
- To compare serum levels of calcitonin gene-related peptide (CGRP), nesfatin-1, and ghrelin in children with and without FD.
- To explore correlations between these peptide levels and FD symptom severity.
Main Methods:
- Serum samples were collected from 38 children with FD and 34 healthy controls.
- Enzyme-linked immunosorbent assay (ELISA) was used to quantify serum CGRP, nesfatin-1, and ghrelin.
- Spearman rank correlation analysis assessed the relationship between peptide levels and clinical symptom scores.
Main Results:
- Children with FD exhibited significantly higher serum nesfatin-1 and CGRP levels compared to controls (P<0.05).
- Ghrelin levels did not differ significantly between groups (P>0.05).
- Nesfatin-1 positively correlated with early satiety, while CGRP correlated with abdominal pain, belching, and overall FD severity.
Conclusions:
- Calcitonin gene-related peptide (CGRP) and nesfatin-1 are implicated in the pathophysiology of functional dyspepsia in children.
- Elevated levels of these peptides may serve as potential biomarkers for pediatric FD.
- Further research is warranted to elucidate the precise mechanisms.
Objectives:
To study the association between functional dyspepsia (FD) and serum levels of brain-gut peptides including calcitonin gene-related peptide (CGRP), nesfatin-1, and ghrelin in children.
Methods:
A total of 38 children with FD who attended Shengjing Hospital of China Medical University from November 2019 to December 2020 were enrolled as the FD group. Thirty-four healthy children were enrolled as the control group. Serum samples were collected from all of the children. Enzyme-linked immunosorbent assay was used to measure serum levels of CGRP, ghrelin, and nesfatin-1 for comparison between the two groups. The scores of clinical symptoms were determined for the children with FD. Spearman rank correlation analysis was used to investigate the correlation of symptom scores with the serum levels of brain-gut peptides.
Results:
The FD group had significantly higher serum levels of nesfatin-1 and CGRP than the control group (P<0.05), while there was no significant difference in the serum level of ghrelin between the two groups (P>0.05). The serum level of nesfatin-1 was positively correlated with the symptom score of early satiety (r=0.553, P<0.001), but was not significantly correlated with the total score of FD (r=0.191, P=0.250). The serum level of CGRP was positively correlated with the scores of abdominal pain (r=0.479, P=0.002) and belching (r=0.619, P<0.001) and the total score of FD (r=0.541, P<0.001).
Conclusions:
CGRP and nesfatin-1 may play an important role in the pathophysiological process of FD.
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