Related Experiment Video

Updated: Sep 24, 2025

Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

33.9K

Nutrition Interventions of Herbal Compounds on Cellular Senescence

Zhongxu Chen1, Yixin Wu1, Qinlu Lin1

  • 1Molecular Nutrition Branch, National Engineering Research Center of Rice and By-product Deep Processing, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, 410004 Hunan, China.

Oxidative Medicine and Cellular Longevity
|May 9, 2022
PubMed

Insights

Cellular senescence drives organ aging and disease. This review explores natural products that may delay senescence, offering insights for managing age-related conditions.

Area of Science:

  • Gerontology and cellular biology
  • Pathology and disease mechanisms
  • Pharmacology and natural product research

Background:

  • Cellular senescence is a key driver of organ aging, leading to irreversible pathology and organismal aging.
  • Understanding senescence mechanisms is crucial for investigating age-related human diseases.
  • Numerous natural compounds show potential in delaying cellular senescence.

Purpose of the Study:

  • To review the characteristics and mechanisms of cellular senescence.
  • To discuss age-related diseases linked to senescence.
  • To summarize recent advancements in natural products targeting cellular senescence for clinical applications.

Main Methods:

  • Literature review of scientific articles on cellular senescence.
  • Analysis of studies on age-related diseases and their mechanisms.
  • Compilation of research on natural products affecting senescence.

Main Results:

  • Cellular senescence contributes significantly to aging and age-related pathologies.
  • Natural products demonstrate potential in modulating senescence pathways.
  • Herbal compounds offer promising therapeutic avenues for age-related diseases.

Conclusions:

  • Cellular senescence is a fundamental process in aging and disease.
  • Natural products represent a viable strategy for mitigating senescence.
  • Further research into these compounds can aid in the clinical management of aging.

More Related Videos

Induction and Validation of Cellular Senescence in Primary Human Cells08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

17.2K
SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs07:39

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs

Published on: June 28, 2019

24.3K

Related Concept Videos

Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
208
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
6.3K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.7K
Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
15.3K