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Synthesis of 68Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /T1Magnetic Resonance Imaging
Published on: November 20, 2018
Functionalization of theranostic AGuIX® nanoparticles for PET/MRI/optical imaging
Vivek Thakare1,2, Vu-Long Tran3,4, Marco Natuzzi3
1Institut de Chimie Moléculaire de l'Université de Bourg, UMR 6302, CNRS, Université Bourgogne Franche-Comté 9 Avenue Alain Savary 21000 Dijon France franck.denat@u-bourgogne.fr.
Abstract:
A novel trifunctional imaging probe containing a chelator of radiometal for PET, a NIR heptamethine cyanine dye, and a bioconjugatable handle, has been grafted onto AGuIX® nanoparticles via a Michael addition reaction. The resulting functionalized nanoparticles have been fully characterized, radiolabelled with 64Cu, and evaluated in a mice TSA tumor model using multimodal (PET/MRI/optical) imaging.
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