Related Experiment Video

Updated: Sep 24, 2025

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
07:31

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

Published on: May 15, 2020

7.2K

Development and Validation of a Prognostic Model to Predict High-Risk Patients for Coronary Heart Disease in Snorers

Meng-Hui Wang1,2,3, Mulalibieke Heizhati1,2,3, Nan-Fang Li1,2,3

  • 1Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region, Ürümqi, China.

Frontiers in Cardiovascular Medicine
|May 9, 2022
PubMed

Insights

This study developed a new risk model for coronary heart disease (CHD) in patients who snore and have uncontrolled hypertension. The model uses age, waist circumference, and cholesterol levels to identify high-risk individuals for early intervention.

Area of Science:

  • Cardiology
  • Sleep Medicine
  • Preventive Medicine

Background:

  • Snoring and obstructive sleep apnea (OSA) are prevalent conditions.
  • Uncontrolled hypertension is a significant risk factor for cardiovascular disease.
  • Combined, OSA and uncontrolled hypertension substantially elevate the risk of coronary heart disease (CHD).

Purpose of the Study:

  • To develop and validate a predictive model for CHD risk.
  • To identify patients with snoring and uncontrolled hypertension who are at high risk for CHD.
  • To aid clinicians in early risk stratification and intervention.

Main Methods:

  • A cohort of 1,822 snorers with uncontrolled hypertension was analyzed.
  • Data were randomly split into training (70%) and validation (30%) sets.
  • A nomogram model was constructed using multivariate Cox regression, incorporating predictors like age, waist circumference, HDL-C, and LDL-C. Internal validation was performed using bootstrapping and C-index analysis.

Main Results:

  • The final model included age, waist circumference (WC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C).
  • The model demonstrated good discrimination, with C-indices of 0.720 in the derivation cohort and 0.703 in the validation cohort.
  • Calibration plots confirmed acceptable consistency between predicted and observed CHD-free survival rates.

Conclusions:

  • A validated CHD risk prediction model was successfully developed for snorers with uncontrolled hypertension.
  • The model, utilizing age, WC, HDL-C, and LDL-C, facilitates early identification of high-risk individuals.
  • This tool can assist clinicians in proactive patient management to mitigate CHD risk.
Abstract

Keywords:
coronary heart diseasehypertensionnomogramprognosissnorer

More Related Videos

A Model to Simulate Clinically Relevant Hypoxia in Humans09:54

A Model to Simulate Clinically Relevant Hypoxia in Humans

Published on: December 22, 2016

9.0K
An R-Based Landscape Validation of a Competing Risk Model05:37

An R-Based Landscape Validation of a Competing Risk Model

Published on: September 16, 2022

2.2K

Related Concept Videos

Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
65
Sleep Apnea01:21

Sleep Apnea

Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
230
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
114
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
78
Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
302
Hypertension V: Nursing Management01:23

Hypertension V: Nursing Management

The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.
55