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Bolaamphiphilic properties and pH-dependent micellization of quercetin polyglycoside
Mahmuda Nargis1, Abu Bin Ihsan1, Yasuhito Koyama1
1Department of Pharmaceutical Engineering, Faculty of Engineering, Toyama Prefectural University 5180 Kurokawa Imizu Toyama 939-0398 Japan ykoyama@pu-toyama.ac.jp.
Abstract:
Quercetin polyglycoside as a new bolaamphiphile is prepared via a one-pot grafting polymerization technique using sugar-based cyclic sulfite. Micelles comprising quercetin polyglycoside exhibit special pH-effects, in which the polyglycoside moieties on the surface of the micelle serve as a steric protecting group to endow chemical stabilization.
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