Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Structure and function of intestinal mucin: developmental aspects.

J D Snyder, W A Walker

    International Archives of Allergy and Applied Immunology
    |January 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Helminth-induced alterations of the gut microbiota exacerbate bacterial colitis.

    Mucosal immunology·2017
    Same author

    Antigen uptake in the gut: immunologic implications.

    Immunology today·2014
    Same author

    The role of gut microbiota in programming the immune phenotype.

    Journal of developmental origins of health and disease·2013
    Same author

    Vaginal calculi in the dolphin.

    Journal of wildlife diseases·2013
    Same author

    Immune factors in breast milk and the development of atopic disease.

    Journal of pediatric gastroenterology and nutrition·2012
    Same author

    Cerebral complications of frontal sinusitis.

    Staff proceedings. Hillcrest Medical Center (Tulsa, Okla.)·2010
    Same journal

    Epidemiology of the relationship between exposure to indoor allergens and asthma.

    International archives of allergy and applied immunology·1991
    Same journal

    T cells and asthma. II. Regulation of the eosinophilia of asthma by T cell cytokines.

    International archives of allergy and applied immunology·1991
    Same journal

    T cells and asthma. I. Lymphocyte subpopulations and activation in allergic and nonallergic asthma.

    International archives of allergy and applied immunology·1991
    Same journal

    Human upper airway epithelial cell-derived granulocyte-macrophage colony-stimulating factor induces histamine-containing cell differentiation of human progenitor cells.

    International archives of allergy and applied immunology·1991
    Same journal

    Detection of antidrug IgG antibodies in patients with adverse drug reactions to amodiaquine.

    International archives of allergy and applied immunology·1991
    Same journal

    Effects of the platelet-activating factor antagonist BN 52021 on anti-islet cytotoxicity of mononuclear cells and serum from type 1 (insulin-dependent) diabetic patients.

    International archives of allergy and applied immunology·1991
    See all related articles

    Mucin glycoproteins protect the intestine, but their structure-function relationship is unclear. Developmental differences in mucin composition and protective mechanisms require further investigation for a complete understanding of intestinal defense.

    Area of Science:

    • Gastroenterology
    • Immunology
    • Biochemistry

    Background:

    • Mucin glycoproteins are crucial for intestinal protection against injury.
    • The precise mechanisms of mucin protection and its structure-function relationship remain incompletely understood.
    • Intestinal mucins exhibit heterogeneity, with regional and developmental variations in composition.

    Purpose of the Study:

    • To investigate the mechanisms of intestinal protection by mucin glycoproteins.
    • To explore the relationship between mucin structure and its protective function.
    • To examine developmental differences in mucin composition and protective roles.

    Main Methods:

    • Structural analysis of purified intestinal mucins.
    • Electrophoretic and buoyant density characterization.

    Related Experiment Videos

  • Assessment of mucin's role in intestinal defense mechanisms.

    • Main Results:

    • Newborn mucin differs from adult mucin in protein/carbohydrate content, density, and mobility.
    • Mucin protection involves release rate, physical barrier, binding sites, and secretory immunoglobulins.
    • Developmental variations may exist in binding sites and immunoglobulin inclusion.

    Conclusions:

    • Mucin's protective function is multifactorial, involving physical and immunological components.
    • Developmental differences in mucin are significant and impact intestinal defense.
    • Mucus acts as a crucial link between physical and immunological intestinal host defense systems.