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Three-Dimensional Culture of Murine Colonic Crypts to Study Intestinal Stem Cell Function Ex Vivo
Published on: October 11, 2022
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Dysplastic Crypts in Asymmetric Branching in Ulcerative Colitis: A Preliminary Report
Carlos A Rubio1, Michael Vieth2, Corinna Lang-Schwarz3
1Department of Pathology, Karolinska Institute, and University Hospital, Stockholm, Sweden.
Cancer Diagnosis & Prognosis
|May 9, 2022
Summary
Dysplastic crypts in asymmetric branching (DCAB) were found in ulcerative colitis (UC) biopsies. This process may lead to rapid expansion of dysplasia in UC patients.
Area of Science:
- Gastroenterology
- Pathology
- Oncology
Background:
- Ulcerative colitis (UC) is a chronic inflammatory bowel disease.
- Dysplasia surveillance is crucial for managing UC patients.
- Early detection of precancerous changes is vital.
Purpose of the Study:
- To report the detection of a specific precancerous feature: dysplastic crypts in asymmetric branching (DCAB).
- To investigate the presence and frequency of DCAB in UC patient biopsies.
Main Methods:
- Review of 100 consecutive endoscopic biopsies from UC patients undergoing surveillance.
- Histopathological examination to identify DCAB.
Main Results:
- DCAB was detected in three out of 100 UC patient biopsies.
- The frequency of DCAB ranged from two to five instances per case.
Conclusions:
- DCAB generates multiple dysplastic offspring-crypts.
- Repeated DCAB events can lead to exponential expansion of dysplastic areas in UC.
- Understanding DCAB is important for UC dysplasia progression.
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