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Updated: Sep 24, 2025
A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
Recent Progress in Systemic Therapy for Hepatocellular Cancer (HCC)
T Tara Ghaziani1, Renumathy Dhanasekaran1
1Division of Gastroenterology and Hepatology, Stanford University, Stanford, CA.
Advanced hepatocellular carcinoma (HCC) treatment has evolved. The combination of atezolizumab and bevacizumab is now a standard first-line therapy, with immunotherapy agents playing a key role.
Area of Science:
- Hepatocellular Carcinoma Research
- Oncology Therapeutics
- Immunotherapy in Cancer
Background:
- Advanced hepatocellular carcinoma (HCC) management has seen significant advancements.
- Recent years have brought new first- and second-line systemic therapies.
Purpose of the Study:
- To review recent progress in advanced HCC treatment.
- To discuss future perspectives in HCC management.
Main Methods:
- Review of phase 3 clinical trial data, including IMBRAVE150.
- Analysis of approved targeted therapies and immunotherapies for HCC.
Main Results:
- The atezolizumab-bevacizumab combination demonstrated superiority over sorafenib in treatment-naive advanced HCC.
- Multiple second-line options are now available, including targeted agents and immunotherapies.
Conclusions:
- Atezolizumab-bevacizumab combination therapy is the new standard for first-line advanced HCC.
- Immunotherapy, alone or combined with targeted therapies, is crucial for future HCC management.
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09:11Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma
Published on: May 24, 2024
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