Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hybrid Zones02:29

Hybrid Zones

20.5K
Hybrid zones are narrow regions where two closely related species interact, mate, and produce hybrids. Relative to either parent species, hybrids may possess distinct phenotypic or genetic differences that impact their survival and reproductive success. The genetic variances introduced by hybridization influence species diversity and speciation processes within the hybrid zone.
20.5K
Speciation Rates01:07

Speciation Rates

21.6K
Overview
21.6K
Inclusive Fitness00:57

Inclusive Fitness

36.4K
Most altruistic behavior—in which one animal helps another at a cost to themselves—occurs between relatives. Scientists think these altruistic behaviors evolved because they increase the inclusive fitness of the animal providing help.
36.4K
Frequency-dependent Selection01:21

Frequency-dependent Selection

22.3K
When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.
22.3K
Distribution and Dispersion00:54

Distribution and Dispersion

22.5K
To understand intra-specific interactions in populations, scientists measure the spatial arrangement of species individuals. This geographic arrangement is known as the species distribution or dispersion. Highly territorial species exhibit a uniform distribution pattern, in which individuals are spaced at relatively equal distances from one another. Species that are highly tied to particular resources, such as food or shelter, tend to concentrate around those resources, and thus exhibit a...
22.5K
Types of Selection01:46

Types of Selection

42.0K
Natural selection influences the frequencies of particular alleles and phenotypes within populations in several different ways. Primarily, natural selection can be directional, stabilizing, or disruptive. Directional selection favors one extreme trait and shifts the population towards that phenotype while selecting against individuals displaying alternate traits. Stabilizing selection favors an intermediate trait with a narrow range of variation. Deviation from the optimal phenotype towards an...
42.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A sibling study of variation in parental mutation rates.

bioRxiv : the preprint server for biology·2026
Same author

What sets the mutation rate of a cell type in an animal species?

bioRxiv : the preprint server for biology·2025
Same author

Occurrence dataset of protected fungal species for the Red Data Book in Yugra Region, Western Siberia.

Biodiversity data journal·2025
Same author

The distribution of highly deleterious variants across human ancestry groups.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Changing selection on amino acid substitutions in Gag protein between major HIV-1 subtypes.

Virus evolution·2024
Same author

Discovery of recessive effect of human polymerase δ proofreading deficiency through mutational analysis of POLD1-mutated normal and cancer cells.

European journal of human genetics : EJHG·2024

Related Experiment Video

Updated: Sep 24, 2025

Daily Transfers, Archiving Populations, and Measuring Fitness in the Long-Term Evolution Experiment with Escherichia coli
15:00

Daily Transfers, Archiving Populations, and Measuring Fitness in the Long-Term Evolution Experiment with Escherichia coli

Published on: August 18, 2023

3.5K

Complex fitness landscape shapes variation in a hyperpolymorphic species.

Anastasia V Stolyarova1, Tatiana V Neretina2,3, Elena A Zvyagina2,4

  • 1Skolkovo Institute of Science and Technology, Moscow, Russian Federation.

Elife
|May 9, 2022
PubMed
Summary

Genetic variation patterns in the highly polymorphic fungus Schizophyllum commune reveal positive epistasis. Compensatory interactions between nonsynonymous alleles shape the fitness landscape, detectable through linkage disequilibrium analysis.

Keywords:
D. melanogasterepistasisevolutionary biologygenetic diversitygeneticsgenomicshumanlinkage disequilibriumpopulation geneticsschizophyllum commune

More Related Videos

Designing Automated, High-throughput, Continuous Cell Growth Experiments Using eVOLVER
07:26

Designing Automated, High-throughput, Continuous Cell Growth Experiments Using eVOLVER

Published on: May 19, 2019

12.2K
A Quantitative Fitness Analysis Workflow
11:39

A Quantitative Fitness Analysis Workflow

Published on: August 13, 2012

14.6K

Related Experiment Videos

Last Updated: Sep 24, 2025

Daily Transfers, Archiving Populations, and Measuring Fitness in the Long-Term Evolution Experiment with Escherichia coli
15:00

Daily Transfers, Archiving Populations, and Measuring Fitness in the Long-Term Evolution Experiment with Escherichia coli

Published on: August 18, 2023

3.5K
Designing Automated, High-throughput, Continuous Cell Growth Experiments Using eVOLVER
07:26

Designing Automated, High-throughput, Continuous Cell Growth Experiments Using eVOLVER

Published on: May 19, 2019

12.2K
A Quantitative Fitness Analysis Workflow
11:39

A Quantitative Fitness Analysis Workflow

Published on: August 13, 2012

14.6K

Area of Science:

  • Evolutionary Biology
  • Genetics
  • Population Genetics

Background:

  • Hyperpolymorphic species offer unique insights into fitness landscapes.
  • Schizophyllum commune is the most genetically polymorphic species known.
  • Understanding genetic variation patterns is key to inferring evolutionary processes.

Purpose of the Study:

  • To investigate genetic variation patterns in Schizophyllum commune.
  • To explore the relationship between linkage disequilibrium (LD) and nonsynonymous variants.
  • To identify signatures of selection and epistasis in a highly polymorphic genome.

Main Methods:

  • Analysis of short-range linkage disequilibrium (LD) across the genome.
  • Comparison of LD between synonymous and nonsynonymous variants.
  • Identification and analysis of haploblocks, indicative of balancing selection.
  • Examination of LD patterns in different populations (USA and Russia).

Main Results:

  • Higher LD observed between nonsynonymous variants compared to synonymous variants.
  • This effect is amplified within genes, particularly those with haploblocks.
  • LD is significantly higher for interacting nonsynonymous amino acid variants.
  • Strong correlation of LD patterns between geographically distinct populations.

Conclusions:

  • Selection in S. commune involves positive epistasis, driven by compensatory interactions between nonsynonymous alleles.
  • Haploblocks are significant genomic features associated with balancing selection.
  • Interspecific comparisons are necessary to detect similar patterns in less polymorphic species.