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Updated: Sep 24, 2025

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
Electrocarboxylation of N-Acylimines with Carbon Dioxide: Access to Substituted α-Amino Acids
Ke Zhang1, Xiao-Fei Liu1, Wen-Zhen Zhang1
1State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, PR China.
Abstract:
Direct electrocarboxylation of various N-acylimines with atmospheric CO2 is achieved in an undivided cell under mild conditions, affording substituted α-amino acids in yields of 62-95%. This reaction is conducted with high efficiency using triethanolamine as an external reductant under nonsacrificial anode conditions, and can be facilely performed on gram scale. Preliminary mechanistic studies including cyclic voltammetry and control experiments support N-radical carbanion as the key intermediate.
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