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Related Experiment Videos

Multiple relapses in borderline leprosy--a case report.

A Ramachandran, P S Seshadri

    Indian Journal of Leprosy
    |October 1, 1986
    PubMed
    Summary
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    This case study highlights leprosy treatment challenges. Dapsone resistance emerged, requiring multi-drug therapy for successful borderline lepromatous leprosy management.

    Area of Science:

    • Dermatology and Infectious Diseases
    • Mycobacterial Infections
    • Leprosy Pathogenesis and Treatment

    Background:

    • Leprosy, a chronic infectious disease caused by Mycobacterium leprae, requires long-term treatment.
    • Dapsone has been a cornerstone of leprosy therapy, but drug resistance is a significant concern.
    • Borderline lepromatous leprosy represents a challenging immunological spectrum of the disease.

    Observation:

    • A patient with borderline lepromatous leprosy initially responded to dapsone monotherapy.
    • The patient experienced relapse with dapsone-resistant leprosy after 3.5 years of continuous dapsone treatment.
    • A second relapse occurred under dapsone therapy, despite previous treatment regimens.

    Findings:

    • Initial dapsone treatment led to clinical inactivity and bacteriological negativity for 3 years.

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  • Subsequent treatment with Rifampicin and dapsone resulted in another period of inactivity.
  • The patient ultimately achieved clinical inactivity within 15 months on a three-drug regimen after the second relapse.

    • Implications:

    • This case underscores the potential for dapsone resistance in borderline lepromatous leprosy.
    • Multi-drug therapy is crucial for managing relapsed or dapsone-resistant leprosy cases.
    • Long-term monitoring is essential for patients with leprosy, even after achieving clinical remission.