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Association of C-Terminal Pro-Endothelin-1 with Mortality in the Population-Based KORA F4 Study

Cornelia Then1,2, Chaterina Sujana2,3,4, Christian Herder5,6,7

  • 1Department of Internal Medicine IV, University Hospital of Ludwigs-Maximilians-University Munich, Munich, Germany.

Vascular Health and Risk Management
|May 10, 2022
PubMed

Insights

C-terminal pro-endothelin-1 (CT-proET-1) is a risk marker for all-cause mortality, independent of cardiovascular disease and inflammation. This study found CT-proET-1 associated with increased mortality but not cardiovascular events or atherosclerosis markers.

Area of Science:

  • Cardiovascular Research
  • Metabolic Disease Research
  • Biomarker Discovery

Background:

  • Endothelin-1 and its precursor CT-proET-1 are implicated in metabolic disorders, inflammation, and cardiovascular events.
  • Previous studies suggest a link between CT-proET-1 and adverse health outcomes in specific populations.

Purpose of the Study:

  • To investigate the association of CT-proET-1 with cardiovascular events, mortality, carotid intima-media thickness, subclinical inflammation biomarkers, and adipokines.
  • To analyze these associations within a general population-based study.

Main Methods:

  • Utilized data from the KORA F4 study with a median follow-up of 9.1 years.
  • Employed multivariable regression and Cox proportional hazard models, adjusting for numerous cardiovascular risk factors.
  • Corrected for multiple testing using the Bonferroni method.

Main Results:

  • CT-proET-1 was significantly associated with increased cardiovascular and all-cause mortality (HRs 1.66 and 2.03, respectively).
  • No association was found with cardiovascular events, but an inverse association with carotid intima-media thickness was observed.
  • CT-proET-1 correlated positively with several subclinical inflammation biomarkers and some adipokines.

Conclusions:

  • CT-proET-1 serves as a risk marker for all-cause mortality, potentially independent of vascular endothelin-1 actions, cardiovascular disease, and inflammation.
  • The findings highlight the complex role of endothelin-1 pathways and the indicator function of CT-proET-1.
Abstract

Keywords:
CT-proET-1cardiovascular eventsendothelinintima-media thicknessmortalitysubclinical inflammation

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