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Correlation between myoferlin expression and lymph node metastasis in papillary thyroid carcinoma.
Ji Min Na1, Dong Chul Kim1,2,3, Dae Hyun Song2,3,4
1Department of Pathology, Gyeongsang National University Hospital, Jinju, Korea.
Journal of Pathology and Translational Medicine
|May 10, 2022
Summary
Myoferlin expression correlates with poorer pathological features in papillary thyroid carcinoma (PTC). Low myoferlin levels are linked to lymph node metastasis, suggesting its prognostic value in PTC.
Area of Science:
- Oncology
- Molecular Biology
- Pathology
Background:
- Myoferlin, a multifunctional protein, exhibits novel oncogenic roles in various cancers.
- Elevated myoferlin expression is increasingly linked to unfavorable prognoses in carcinomas.
- Its specific prognostic significance in papillary thyroid carcinoma (PTC), particularly concerning nodal metastasis, warrants investigation.
Purpose of the Study:
- To investigate the prognostic role of myoferlin expression in papillary thyroid carcinoma (PTC).
- To specifically examine the association between myoferlin expression and lymph node metastasis in PTC patients.
Main Methods:
- Clinicopathological data and PTC tissues from 116 patients were collected.
- Immunohistochemical analysis was performed on tissue microarrays to grade myoferlin expression.
- The relationship between myoferlin expression levels and tumor pathological features was evaluated using the AJCC staging system.
Main Results:
- Myoferlin expression was positive in 100 out of 116 PTC cases.
- Higher myoferlin expression correlated with a lower T category (p = .010).
- Low-grade myoferlin expression was significantly associated with lymph node metastasis (p = .019), irrespective of pN1a/pN1b substage.
Conclusions:
- Myoferlin expression shows an adverse correlation with pathological features in PTC.
- Myoferlin may serve as a potential prognostic biomarker for lymph node metastasis in PTC.
