Metal-Phenolic Networks as Versatile Coating Materials for Biomedical Applications

Polyphenols are naturally derived organic compounds that have long been used as food additives, antioxidants, and adhesives owing to their intrinsic physicochemical properties. Recently, there has been growing interest in the fabrication of coordination networks based on the self-assembly of polyphenols and metal ions, termed metal-phenolic networks (MPNs), for multiple biological applications including bioimaging, drug delivery, and cell encapsulation. The as-synthesized MPN complexes feature pH responsiveness, controllable size and rigidity, and tunable permeability based on the choice of polyphenol-metal ion pairs. The aim of this Review is to introduce the physicochemical properties of MPNs, highlight their recent biological applications in cancer theranostics and single-cell encapsulation, and discuss the future utility of MPNs for biomedical applications.