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Updated: Sep 24, 2025

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
Published on: August 2, 2016
Absorption behavior of doxorubicin hydrochloride in visible region in different environments: a combined experimental
Cheng Giuseppe Chen1, Alessandro Nicola Nardi1, Mauro Giustini1
1Department of Chemistry, Sapienza University of Rome, Rome, Italy. marco.dabramo@uniroma1.it.
Abstract:
The experimental absorption measurements in the interval 350-600 nm (Vis), molecular dynamics simulations, quantum-mechanics calculations and an advanced molecular treatment of simulation data are here combined to provide a complete picture of the absorption behavior in the visible portion of the electromagnetic spectrum of the doxorubicin hydrochloride (DX) molecule in different environments. By such an approach, we have shown that it is possible to characterize the effect of the environment on the DX absorption behavior - including the vibronic contributions - as well as to interpret such differences in terms of molecular electronic excited states, which are found to be strongly influenced by the environment.
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