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Avelumab First-Line Maintenance Treatment in Advanced Bladder Cancer: Practical Implementation Steps for Infusion
Laura S Wood1,2,3,4,5,6,7,8,9, Dawn Conway1,2,3,4,5,6,7,8,9, Maria Lapuente1,2,3,4,5,6,7,8,9
1Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio (Ms Wood); University of Chicago Medicine, Genitourinary Oncology, Chicago, Illinois (Ms Conway); St Bartholomew's Hospital, London, United Kingdom (Ms Lapuente, Mr Salvador, Ms Fernandez Gomez); St George's Hospital, London, United Kingdom (Ms Fernandez Gomez); EMD Serono, Rockland, Massachusetts (Ms Carroll Bullock); Pfizer Inc, New York, New York (Dr Devgan); City of Hope Medical Center, Genitourinary Medical Oncology, Duarte, California (Ms Burns).
Avelumab as first-line maintenance therapy is the standard of care for advanced urothelial carcinoma (UC) after chemotherapy. This review covers essential information for nurses on avelumab
Area of Science:
- Oncology
- Immunotherapy
Background:
- Advanced urothelial carcinoma (UC) treatment relies on immune checkpoint inhibitors.
- Programmed cell death ligand 1 (PD-L1) inhibitors like avelumab are crucial in UC therapy.
Purpose of the Study:
- To review key considerations for infusion nurses regarding first-line (1L) avelumab maintenance therapy in advanced UC.
- To ensure safe and effective administration and management of avelumab therapy.
Main Methods:
- Review of data from the phase 3 JAVELIN Bladder 100 trial.
- Analysis of National Comprehensive Cancer Network Clinical Practice Guidelines.
Main Results:
- Avelumab 1L maintenance is the standard of care for advanced UC patients responding to or stabilizing after 1L platinum-based chemotherapy.
- Avelumab is the only Category 1 preferred maintenance checkpoint inhibitor option in NCCN guidelines for UC.
Conclusions:
- Infusion nurses require specific knowledge on avelumab dosing, administration, and adverse event management.
- Safe and appropriate use of avelumab is vital for patients with advanced UC.
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