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Updated: Sep 24, 2025

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Biomimetic total synthesis of (-)-galanthamine via intramolecular anodic aryl-phenol coupling
Ziyue Xiong1, Frauke Weidlich1, Camille Sanchez1
1School of Chemistry, Cardiff University, Park Place, Main Building, Cardiff CF10 3AT, Cymru/Wales, UK. wirth@cf.ac.uk.
Abstract:
(-)-Galanthamine as a drug for the treatment of Alzheimer's disease has attracted synthetic chemists for decades. However, previous total synthetic and biomimetic approaches often use stoichiometric oxidants (metal oxidants or hypervalent iodine) to prepare the target product. Anodic oxidative coupling offers a sustainable alternative method which is, for the first time, successfully applied to the total synthesis of (-)-galanthamine. We report a new asymmetric total synthesis of (-)-galanthamine by using an anodic aryl-phenol coupling as the key synthetic step.
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