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Hyponatremia with Antidepressant: A Rare Side Effect from Duloxetine in a Child with Acute Leukemia
Muhammad Usman Baig1, Kevin Madden2, Karen Moody2
1Division of Pediatric Hematology/Oncology, Department of Pediatrics, Loma Linda University, Loma Linda, California, USA.
Abstract:
Duloxetine is indicated for the treatment of chemotherapy-induced neuropathic pain in adults. It is also indicated for anxiety, depression, and fibromyalgia in children. A rare side effect of syndrome of inappropriate antidiuretic hormone (SIADH) secretion has been reported in adults, but not in pediatrics or pediatric oncology patients. We present the case of a 10-year-old child with acute lymphoblastic leukemia, who developed SIADH after duloxetine was given for chemotherapy-induced neuropathic pain and comorbid anxiety. The SIADH resolved after duloxetine was stopped. This case highlights a rare side effect of duloxetine and caution should be taken when prescribing duloxetine to children.
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