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Inflammatory comorbidities: to train or not to train?
Suhas Bobba1, Shabaana A Khader1
1Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Abstract:
Inflammatory stimuli reprogram innate immune cells to generate rigorous responses to future challenge with heterologous stimuli through trained immunity. Li et al. show that training of hematopoietic stem cells (HSCs) in the bone marrow primes cells to generate more inflammatory myeloid progeny and, thereby, mechanistically links inflammatory comorbidities.
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