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Effect of Sodium Fluoride on Reproductive Function Through Regulating Reproductive Hormone Level and Circulating

Siyuan Dong1, Yanni Yang2, Biqi He3

  • 1Guipei Class s0141, Xi'an Jiaotong University Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, People's Republic of China.

Biological Trace Element Research
|May 10, 2022
PubMed
Summary

Sodium fluoride (NaF) exposure in female rats impairs reproductive function and fertility by disrupting hormone secretion and ovarian estradiol release. Silent Information Regulator 1 (SIRT1) may play a role in this NaF-induced dysfunction.

Keywords:
FluorosisNaFReproductive functionSIRT1Steroid hormone

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Area of Science:

  • Toxicology
  • Reproductive Biology
  • Endocrinology

Background:

  • Fluorosis is linked to female reproductive issues, but its underlying mechanisms remain unclear.
  • Sodium fluoride (NaF) exposure is a potential contributor to reproductive dysfunction and reduced fertility.

Purpose of the Study:

  • To investigate the effects of varying sodium fluoride (NaF) concentrations and exposure durations on female rat reproductive health.
  • To elucidate the potential role of Silent Information Regulator 1 (SIRT1) in NaF-induced reproductive dysfunction.

Main Methods:

  • Sprague-Dawley female rats were exposed to 0, 50, 100, or 150 mg/L NaF in drinking water for 2, 4, or 6 months.
  • Evaluated estrous cycle, mating performance, fertility rates, serum hormone levels (steroid hormones, SIRT1), and urinary fluoride concentrations.

Main Results:

  • High NaF doses reduced body weight and significantly decreased serum steroid hormone levels and pregnancy rates.
  • Urinary fluoride concentration increased with exposure duration, while serum SIRT1 levels elevated.
  • NaF exposure inhibited ovarian estradiol release and affected FSH and LH secretion.

Conclusions:

  • Sodium fluoride (NaF) exposure negatively impacts female reproductive function and fertility in rats.
  • NaF inhibits hormone secretion and estradiol release, leading to reduced pregnancy rates.
  • SIRT1 may be implicated in NaF-induced reproductive dysfunction by modulating reproductive hormone secretion.