Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Corticosteroid agents in renal disease.

N M Thomson

    The Medical Journal of Australia
    |May 18, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Corticosteroids are crucial for immune-based kidney diseases like minimal-change glomerulonephritis. While their role varies, they offer significant benefits in conditions such as lupus nephritis and vasculitis, and historically in preventing transplant rejection.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A robust route to enzymatically functional, hierarchically self-assembled peptide frameworks.

    Advanced materials (Deerfield Beach, Fla.)·2013
    Same author

    Dysregulated growth factor gene expression is associated with tubulointerstitial apoptosis and renal dysfunction.

    Kidney international·2007
    Same author

    Apoptosis and the expression of genes of the Bcl-2 family and TGF-beta1 in rat renal allografts transplanted after donor-specific blood transfusion.

    Transplantation proceedings·2005
    Same author

    Proteinuria and the expression of the podocyte slit diaphragm protein, nephrin, in diabetic nephropathy: effects of angiotensin converting enzyme inhibition.

    Diabetologia·2002
    Same author

    Transforming growth factor-beta1 and tumor growth factor-beta-inducible gene-H3 in nonrenal transplant cyclosporine nephropathy.

    Transplantation·2001
    Same author

    Interactions between methylating and pyridyloxobutylating agents in A/J mouse lungs: implications for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis.

    Cancer research·2001

    Area of Science:

    • Nephrology
    • Immunology
    • Pharmacology

    Background:

    • Corticosteroids are frequently used to manage immune-mediated renal diseases.
    • Their efficacy and optimal use vary across different glomerular conditions.

    Purpose of the Study:

    • To review the role and effectiveness of corticosteroid agents in various immune-based renal disorders.
    • To highlight the current status of corticosteroid therapy in nephrology.

    Main Methods:

    • Review of existing literature and clinical trial data on corticosteroid use in glomerulonephritis.
    • Analysis of treatment outcomes in conditions like minimal-change glomerulonephritis, membranous glomerulonephritis, and lupus nephritis.

    Main Results:

    • Corticosteroids induce remission in over 90% of minimal-change glomerulonephritis cases.

    Related Experiment Videos

  • Evidence supports corticosteroid use in rapidly progressive glomerulonephritis and lupus-associated glomerulonephritis.
  • Their role in membranous glomerulonephritis is debated, but some evidence suggests benefit.
  • Corticosteroids were standard for renal allograft rejection prevention but are now often replaced by other agents.

    • Conclusions:

    • Corticosteroids remain a cornerstone treatment for specific immune-related kidney diseases.
    • Treatment protocols are evolving, with reduced doses or alternative agents like cyclosporin A gaining prominence.
    • The judicious use of corticosteroids, often with immunosuppressants, continues to improve patient prognosis in select renal conditions.