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The influence of killed Propionibacterium granulosum on experimental infection with Escherichia coli

H Hof, G Pulverer

    Medical Microbiology and Immunology
    |January 1, 1987
    PubMed

    Insights

    Propionibacterium granulosum pretreatment protected mice against lethal Escherichia coli infection, reducing bacterial liver counts. This immunotherapy enhanced resistance to bacterial systemic infection.

    Area of Science:

    • Immunology
    • Microbiology
    • Infectious Diseases

    Background:

    • Systemic infections caused by Escherichia coli can be lethal.
    • The use of bacterial components as immunomodulators is an area of research.

    Purpose of the Study:

    • To investigate the protective effect of killed Propionibacterium granulosum KP-45 against Escherichia coli infection in mice.

    Main Methods:

    • Mice were infected subcutaneously with Escherichia coli ATCC 25922.
    • Mice were pretreated intraperitoneally with killed Propionibacterium granulosum KP-45.
    • Bacterial counts in the liver and spleen weight were assessed.

    Main Results:

    • Escherichia coli infection led to systemic infection and death in mice within 6 days.
    • Pretreatment with Propionibacterium granulosum KP-45 increased spleen weight.
    • Pretreated mice showed significantly lower bacterial counts in the liver compared to controls, indicating protection.

    Conclusions:

    • Killed Propionibacterium granulosum KP-45 confers protection against systemic Escherichia coli infection in mice.
    • This suggests a potential immunotherapeutic strategy for bacterial infections.

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