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Updated: Sep 23, 2025

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
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Differential BMP Signaling Mediates the Interplay Between Genetics and Leaflet Numbers in Aortic Valve Calcification

Jae-Joon Jung1,2, Azmi A Ahmad1,2, Saranya Rajendran1,2

  • 1Section of Cardiovascular Medicine and Cardiovascular Research Center, Yale University School of Medicine, New Haven, Connecticut, USA.

JACC. Basic to Translational Science
|May 11, 2022
PubMed

Keywords:
BAV, bicuspid aortic valveBMP, bone morphogenic proteinCAVD, calcific aortic valve diseaseDCBLD2, discoidin, CUB and LCCL domain containing 2EC, endothelial cellRT-PCR, reverse-transcription polymerase chain reactionSMAD, homolog of Caenorhabditis elegans Sma and the Drosophila mad, mothers against decapentaplegicTAV, tricuspid aortic valveVIC, valvular interstitial cellWT, wild typeaortic stenosisaortic valvebicuspid aortic valvecalcificationmouse modelspVIC, porcine valvular interstitial cellsiRNA, small interfering RNA

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