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Updated: Sep 23, 2025

Efficient Derivation of Human Cardiac Precursors and Cardiomyocytes from Pluripotent Human Embryonic Stem Cells with Small Molecule Induction
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Nicotinamide Mononucleotide Alleviates Cardiomyopathy Phenotypes Caused by Short-Chain Enoyl-Coa Hydratase 1

Ke Cai1, Feng Wang1, Jia-Quan Lu1

  • 1NHC Key Laboratory of Neonatal Diseases, Cardiovascular Center, Children's Hospital of Fudan University, State Key Laboratory of Genetic Engineering, and School of Life Sciences, Fudan University, Shanghai, China.

JACC. Basic to Translational Science
|May 11, 2022
PubMed

Keywords:
ANP, atrial natriuretic peptideBCAA, branched-chain amino acidBNP, brain natriuretic peptideDCM, dilated cardiomyopathyECHS1, short-chain enoyl-CoA hydratase 1FA, fatty acidHCM, hypertrophic cardiomyopathyHFF, human foreskin fibroblastIVSd, interventricular septum in end-diastoleIVSs, interventricular septum in end-systoleLVEF, left ventricular ejection fractionLVFS, left ventricular fractional shorteningLVIDd, left ventricular internal dimension in end-diastoleLVIDs, left ventricular internal dimension in end-systoleLVPWd, left ventricular posterior wall in end-diastoleLVPWs, left ventricular posterior wall in end-systoleNMN, nicotinamide mononucleotideacetylation of H3K9cardiomyopathyenoyl-CoA hydratase 1nicotinamide mononucleotidep300α-SMA, smooth muscle actin-α

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