Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Esters to Carboxylic Acids: Acid-Catalyzed Hydrolysis01:13

Esters to Carboxylic Acids: Acid-Catalyzed Hydrolysis

3.2K
Hydrolysis of esters under acidic conditions proceeds through a nucleophilic acyl substitution. In the presence of excess water, the reaction proceeds in a reversible manner, forming carboxylic acids and alcohols.
During hydrolysis, the ester is first activated towards nucleophilic attack through the protonation of the carboxyl oxygen atom by the acid catalyst. The protonation makes the ester carbonyl carbon more electrophilic. In the next step, water acts as a nucleophile and adds to the...
3.2K
Carboxylic Acids to Esters: Acid-Catalyzed (Fischer) Esterification Overview01:20

Carboxylic Acids to Esters: Acid-Catalyzed (Fischer) Esterification Overview

18.6K
The Fischer esterification reaction was developed by the German chemist Emil Fischer in 1895. It is a condensation reaction between carboxylic acids and alcohols in an acidic medium to give esters and water.
18.6K
Carboxylic Acids to Esters: Acid-Catalyzed (Fischer) Esterification Mechanism01:13

Carboxylic Acids to Esters: Acid-Catalyzed (Fischer) Esterification Mechanism

8.2K
Carboxylic acids react with alcohols to yield esters via an acid-catalyzed condensation reaction called Fischer esterification. This is a nucleophilic acyl substitution reaction that proceeds via a tetrahedral intermediate, where a water molecule is eliminated as the leaving group.
8.2K
Acid Halides to Esters: Alcoholysis01:12

Acid Halides to Esters: Alcoholysis

3.1K
Alcoholysis is a nucleophilic acyl substitution reaction in which an alcohol functions as a nucleophile. Acid halides react with alcohol to produce esters. The mechanism proceeds in three steps:
3.1K
Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide02:44

Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide

10.9K
Alkenes are converted to 1,2-diols or glycols through a process called dihydroxylation. It involves the addition of two hydroxyl groups across the double bond with two different stereochemical approaches, namely anti and syn. Dihydroxylation using osmium tetroxide progresses with syn stereochemistry.
10.9K
Esters to Carboxylic Acids: Saponification01:25

Esters to Carboxylic Acids: Saponification

4.8K
Esters can be hydrolyzed to carboxylic acids under acidic or basic conditions. Base-promoted hydrolysis of esters is a nucleophilic acyl substitution reaction in which esters react with an aqueous base, followed by an acid to give carboxylic acids. This reaction is also known as saponification because it forms the basis for making soaps from fats.
The reaction requires a base in stoichiometric amounts, which participates in the reaction and is not regenerated later. So, the base acts as a...
4.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Network-Texture-Induced Uniform Nucleation: Controllable Preparation and Application of High-Performance CsPbI<sub>3</sub> Nanocrystals in Al<sup>3+</sup>/Gd<sup>3+</sup> Co-Doped Glass.

Inorganic chemistry·2026
Same author

Gradient-Aminated Hollow Fiber Membranes Enable Moisture-Synergized Facilitated Transport for Anesthetic Xenon Recovery.

Journal of the American Chemical Society·2026
Same author

Anomalous luminescence properties in Dy<sup>3+</sup>-doped Bi<sub>2</sub>O<sub>3</sub>-B<sub>2</sub>O<sub>3</sub>-SiO<sub>2</sub> glasses at high silver concentrations.

Applied optics·2026
Same author

Is Coffee Consumption Associated With Increased Risk of Atrial Fibrillation: A Systematic Review and a Meta-Analysis.

Pacing and clinical electrophysiology : PACE·2026
Same author

Selective Electrosynthesis of Ethanol from CO<sub>2</sub> Enabled by High Cu<sup>I</sup> Content and Enhanced H<sub>2</sub>O Activation of Molecularly Modified Cu-Based Catalyst.

Journal of the American Chemical Society·2026
Same author

Catalytic ignition of the [BMIM]DCA-H<sub>2</sub>O<sub>2</sub> propellant with the Cu(vim)<sub>2</sub>(DCA)<sub>2</sub> complex.

RSC advances·2026
Same journal

A multifunctional octacalcium phosphate pentahydrate with dual environmental and biomedical functions: efficient dye removal, potent antimicrobial activity, and ionic regulation in physiological media.

RSC advances·2026
Same journal

Research progress on immobilized penicillin G acylase and industrial applications.

RSC advances·2026
Same journal

Recycling of expired Ceporex drug (CPX) as a corrosion inhibitor for carbon steel in a hydrochloric acid medium.

RSC advances·2026
Same journal

Fibrillation/defibrillation of myoglobin decorated with gold nanoparticles probed through nanometal surface energy transfer mechanism.

RSC advances·2026
Same journal

Recent advances in the synthesis and applications of cyanuric acid and its related analogues: a comprehensive review.

RSC advances·2026
Same journal

Effects of fluid flow and solute transport on anorthite dissolution rates in heterogeneous pore networks.

RSC advances·2026
See all related articles

Related Experiment Video

Updated: Sep 23, 2025

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
08:25

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs

Published on: January 17, 2020

7.4K

Acidic ionic liquid based UiO-67 type MOFs: a stable and efficient heterogeneous catalyst for esterification.

Zichen Xu1,2, Guoying Zhao1, Latif Ullah1

  • 1CAS Key Laboratory of Green Process and Engineering, State Key Laboratory of Multiphase Complex System, Beijing Key Laboratory of Ionic Liquids Clean Process, Institute of Process Engineering, Chinese Academy of Sciences Beijing 100190 China sjzhang@ipe.ac.cn hfdong@ipe.ac.cn +86-010-82544875 +86-010-82544875.

RSC Advances
|May 11, 2022
PubMed
Summary
This summary is machine-generated.

This study developed new acidic ionic liquid catalysts based on UiO-67 metal-organic frameworks. These heterogeneous catalysts show excellent activity and stability for esterification reactions, offering a promising alternative for acid catalysis.

More Related Videos

Highly Stereoselective Synthesis of 1,6-Ketoesters Mediated by Ionic Liquids: A Three-component Reaction Enabling Rapid Access to a New Class of Low Molecular Weight Gelators
06:31

Highly Stereoselective Synthesis of 1,6-Ketoesters Mediated by Ionic Liquids: A Three-component Reaction Enabling Rapid Access to a New Class of Low Molecular Weight Gelators

Published on: November 27, 2015

9.7K
Tuning the Acidity of Pt/ CNTs Catalysts for Hydrodeoxygenation of Diphenyl Ether
09:21

Tuning the Acidity of Pt/ CNTs Catalysts for Hydrodeoxygenation of Diphenyl Ether

Published on: August 17, 2019

9.1K

Related Experiment Videos

Last Updated: Sep 23, 2025

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
08:25

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs

Published on: January 17, 2020

7.4K
Highly Stereoselective Synthesis of 1,6-Ketoesters Mediated by Ionic Liquids: A Three-component Reaction Enabling Rapid Access to a New Class of Low Molecular Weight Gelators
06:31

Highly Stereoselective Synthesis of 1,6-Ketoesters Mediated by Ionic Liquids: A Three-component Reaction Enabling Rapid Access to a New Class of Low Molecular Weight Gelators

Published on: November 27, 2015

9.7K
Tuning the Acidity of Pt/ CNTs Catalysts for Hydrodeoxygenation of Diphenyl Ether
09:21

Tuning the Acidity of Pt/ CNTs Catalysts for Hydrodeoxygenation of Diphenyl Ether

Published on: August 17, 2019

9.1K

Area of Science:

  • Materials Science
  • Catalysis
  • Green Chemistry

Background:

  • Developing efficient and reusable heterogeneous acid catalysts is crucial for sustainable chemical synthesis.
  • Metal-organic frameworks (MOFs) offer tunable structures for catalyst design.
  • Ionic liquids possess unique properties that can enhance catalytic performance.

Purpose of the Study:

  • To synthesize novel acidic ionic liquid-based UiO-67 MOFs.
  • To investigate their structural and chemical properties.
  • To evaluate their catalytic performance in esterification reactions.

Main Methods:

  • Facile synthesis of UiO-67-bpy MOFs incorporating Brønsted acids (H2SO4, CF3SO3H, hifpOSO3H).
  • Characterization using XRD, SEM, FT-IR, EA, TGA, and N2 adsorption-desorption.
  • Catalytic evaluation via esterification of acetic acid with isooctyl alcohol.

Main Results:

  • UiO-67-based acidic ionic liquid catalysts (UiO-67-HSO4, UiO-67-CF3SO3, UiO-67-hifpOSO3) were successfully synthesized.
  • High surface area was maintained with uniformly dispersed acidic groups.
  • UiO-67-CF3SO3 achieved 98.6% isooctyl alcohol conversion, demonstrating high catalytic activity.
  • Catalysts exhibited excellent stability and reusability over five cycles with minimal leaching.

Conclusions:

  • A facile strategy for creating heterogeneous acidic ionic liquid catalysts based on UiO-67 MOFs was established.
  • The synthesized catalysts demonstrate significant potential for applications in acid catalysis.
  • This work provides a pathway for designing isolated, well-defined acidic sites in MOFs for enhanced catalytic processes.