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Updated: Sep 23, 2025
Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
Auxiliary-directed etherification of sp2 C-H bonds under heterogeneous metal-organic framework catalysis: synthesis
Chau B Tran1, Xuan N T Duong1, Huy D Lu1
1Department of Chemical Engineering, Ho Chi Minh University of Technology, VNU-HCM 268 Ly Thuong Kiet, District 10 Ho Chi Minh City Viet Nam truongvuthanh@gmail.com tvthanh@hcmut.edu.vn +84 8 38637504 +84 8 38647256 ext. 5681.
Abstract:
An efficient protocol for 8-aminoquinoline assisted alkoxylation and phenoxylation of sp2 C-H bonds under heterogeneous catalysis was developed. The optimal conditions employed Cu-MOF-74 (20%), K2CO3 base, pyridine ligand or dimethyl formamide solvent, and O2 oxidant at 80 °C or 100 °C for 24 hours. Cu-MOF-74 revealed remarkably higher activity when compared with other previously commonly used Cu-MOFs in cross coupling reactions, supported copper catalysts, and homogeneous copper salts. The reaction scope with respect to coupling partners included a wide range of various substrates. Interestingly, the developed conditions are applicable for the synthesis of high-profile relevant biological agents from easily accessible starting materials. Furthermore, a leaching test confirmed the reaction heterogeneity and the catalyst was reused and recycled at least 8 times with trivial degradation in activity.
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