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Updated: Oct 26, 2026

Facile Preparation of (2Z,4E)-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Dehydrogenative Aminooxygenation of Cyclopropylamides Enabled by Cooperative Electrocatalysis
Ming Chen1, Wenda Li1, Haolin Jiang1
1School of Chemistry and Pharmacy Engineering, Nanyang Normal University, Nanyang473061, China.
Abstract:
Herein, we report an unprecedented, sustainable, and atom-economic electrochemical [3 + 3] annulation of cyclopropylamides. Readily accessible amides, carbamates, and ureas serve as dual N/O-functional precursors to precisely steer reaction regiochemistry. This protocol allows straightforward assembly of structurally diversified 1,3-oxazines with exclusive regiocontrol under mild conditions. The developed strategy features excellent functional group tolerance, broad substrate scope, and good scalability at higher reaction concentrations and is also applicable to the late-stage modification of bioactive molecules. Mechanistic studies support a distinctive pathway mediated by synergistic ferrocene/iodide dual catalysis.
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