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Updated: Oct 26, 2026

Facile Preparation of (2Z,4E)-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Halophosphoryloxylation of Alkenes via Cooperative Activation between a Lewis Base and a Silyl-Based Lewis Acid
Keigo Nagami1, Shuhei Ohmura1, Kazuaki Ishihara1
1Graduate School of Engineering, Nagoya University, B2-3(611) Furo-cho, Chikusa, Nagoya464-8603, Japan.
Abstract:
A new strategy for the catalytic halophosphoryloxylation of alkenes via the cooperative activation between a Lewis base and a silyl-based Lewis acid has been developed. The N-silylation of allyl phosphoramidates enabled an unprecedented halocyclization, furnishing the desired 1,2-halophosphoryloxylated compounds in high yield. Several control experiments indicated that the interaction between the silyl group and chloride ion plays an important role in determining both the reactivity and the chemoselectivity of the reaction.
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