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Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
Published on: October 10, 2016
Synthesis of phosphine oxide based amphiphilic molecules via ring-opening Wittig olefination of a macrocyclic
Jin Xu1, Anqi Chen1, Brendan Burkett1
1Organic Chemistry, Institute of Chemical and Engineering Sciences (ICES), ASTAR 8 Biomedical Grove, Neuros #07-01, 138665 Singapore xu_jin@ices.a-star.edu.sg chankp75@hotmail.com.
Abstract:
A novel ring-opening Wittig olefination approach was developed for the synthesis of amphiphilic phosphine oxides (PO) as non-ionic surfactants. The approach concurrently introduces the crucial functional groups (lipophilic chain and phosphine oxide moiety) present in the known PO surfactants and additional hydrophilic group (i.e., ethylene glycol units) in one step via Wittig olefination of a macrocyclic phosphoranylidene. A series of novel PO compounds were obtained from a variety of aldehydes and selected compounds were examined for their physiochemical properties (surface tension, critical micelle concentration and interfacial tension) and also for their abilities to form emulsions as non-ionic surfactants.
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