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Updated: Sep 23, 2025
High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies
Published on: January 4, 2015
An innovative small molecule for promoting neuroreparative strategies
Nicola Antonio Colabufo1,2, Marialessandra Contino1, Mariangela Cantore2
1Dipartimento di Farmacia-Scienze del Farmaco, University of Bari "Aldo Moro" via Orabona 4 70125 Bari Italy nicolaantonio.colabufo@uniba.it.
Abstract:
In this study, a new regenerative strategy to treat several neurodegenerative diseases is suggested by the use of a multitarget approach induced by our small molecule, MC111. Considering the importance of P-gp and BCRP expression on stem cell differentiation and the involvement of TLR4 on neurodegeneration processes, we investigated the effect of MC111, belonging to our library of P-gp active compounds on: (i) TLR4 signaling; (ii) P-gp and BCRP activity and expression; (iii) neurite sprouting. The observed findings exerted by MC111, open a new scenario for a multitarget and regenerative approach in neurodegenerative diseases encouraging the in vivo evaluation of MC111 as new tool in neuroreparative medicine.
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