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Ambulatory pulse pressure and its contributors in autosomal dominant polycystic kidney disease

Agata Koska-Ścigała1, Magdalena Jankowska2, Anna Szyndler3

  • 1Department of Neurology, Regional Hospital in Elbląg, Poland.

Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University
|May 11, 2022
PubMed

Insights

Autosomal dominant polycystic kidney disease (ADPKD) patients show normal ambulatory pulse pressure (PP). PP increases with age and male sex, and decreases with kidney function, but is not linked to hypertension diagnosis.

Area of Science:

  • Cardiology
  • Nephrology
  • Hypertension Research

Background:

  • Pulse pressure (PP) is a key blood pressure component linked to arterial stiffness and prognosis.
  • Autosomal dominant polycystic kidney disease (ADPKD) involves multifactorial cardiovascular issues, suggesting potential for increased PP.

Purpose of the Study:

  • Investigate ambulatory PP in ADPKD patients.
  • Examine the influence of age, sex, kidney function, hypertension, circadian rhythm, and antihypertensive drugs on PP in ADPKD.

Main Methods:

  • Retrospective analysis of 24-hour ambulatory blood pressure monitoring in 130 ADPKD patients.
  • Data collected included demographics, medical history, antihypertensive treatment, and estimated glomerular filtration rate (eGFR).
  • ADPKD diagnosis followed Pei et al. criteria; eGFR calculated using CKD-EPI equation.

Main Results:

  • Mean PP was 46 mm Hg, higher in men and during daytime versus nighttime.
  • PP showed negative correlation with eGFR and positive correlation with age.
  • No significant difference in PP between ADPKD patients with or without hypertension diagnosis.

Conclusions:

  • Ambulatory PP is not substantially elevated in ADPKD patients across CKD stages.
  • PP patterns in ADPKD align with expected physiological changes: increasing with age, male sex, daytime, and decreasing eGFR.
  • Hypertension diagnosis did not significantly impact PP levels in this ADPKD cohort.
Abstract

Keywords:
ADPKDhypertensionpulse pressure

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