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β-Galactosidase-activated theranostic for hepatic carcinoma therapy and imaging
Mrinmoy Maiti1, Kai Kikuchi2,3, K K Athul4
1Department of Science, Amrita School of Engineering, Amrita Viswa Vidyapeetham, Coimbatore, India, 641112.
Abstract:
A β-galactosidase activatable fluorescent turn-on theranostic Gal-CGem exhibits gemcitabine release specifically in β-galactosidase overexpressing hepatic carcinoma cells. The cytotoxicity of Gal-CGem in cancer cells is achieved through the apoptotic cell death pathway. Overall, Gal-CGem is a new frontline prodrug in cancer therapy that has provided antineoplastic information through fluorescence imaging.
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