Related Experiment Video
Updated: Sep 23, 2025
Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats
Published on: August 1, 2018
[Liver manifestation of circulatory disorders]
1Liver Research Center, Beijing Friendship Hospital, Capital Medical University; Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis & National Clinical Research Center for Digestive Diseases, Beijing 100050, China.
Insights
Congestive hepatopathy and ischemic hepatitis stem from liver circulatory issues like increased venous pressure and reduced cardiac output. This review covers their causes, symptoms, and treatments for better clinical practice.
Area of Science:
- Hepatology
- Cardiovascular Medicine
- Gastroenterology
Background:
- The liver has a rich blood supply, receiving 25% of cardiac output.
- Circulatory disorders can lead to hepatic injury, causing congestive hepatopathy (CH) and ischemic hepatitis (IH).
- Hepatic congestion, due to elevated hepatic venous pressure and diminished cardiac output, underlies both CH and IH.
Purpose of the Study:
- To review the pathophysiology, clinical manifestations, and therapeutic interventions for congestive hepatopathy and ischemic hepatitis.
- To provide a clinical practice reference for managing liver circulatory disorders.
Main Methods:
- Literature review of existing studies on hepatic circulatory disorders.
- Synthesis of information on the pathophysiology, clinical presentation, and treatment of CH and IH.
Main Results:
- Identified shared pathophysiological basis for CH and IH: hepatic congestion.
- Highlighted the role of arteriovenous shunts in altering portal pressure, cardiac function, and hepatic blood supply.
- Summarized clinical features and current therapeutic strategies.
Conclusions:
- Understanding the common pathophysiology is crucial for diagnosing and managing CH and IH.
- Arteriovenous shunts significantly impact liver hemodynamics and cardiac function.
- This review offers valuable insights for clinicians managing patients with liver circulatory disorders.
Abstract:
The liver is abundant in blood supply and receives 25% of the cardiac output via the hepatic artery and portal vein. Circulatory disorders may cause hepatic injury, resulting in congestive hepatopathy(CH) and ischemic hepatitis(IH). Hepatic congestion arising from increased hepatic venous pressure and decreased cardiac output is the common pathophysiological basis of both CH and IH. In addition, extensive arteriovenous shunts affect portal pressure and cardiac function, leading to alterations of hepatic blood supply. The current review summarizes the pathophysiology, clinical manifestations and therapeutic interventions of the above diseases, in order to provide reference for clinical practice.
Related Concept Videos
01:26Diseases of the Liver and Gallbladder
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
01:28Esophageal Varices-II: Clinical Features and Management
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
01:26Heart Failure III: Clinical Manifestations
01:30Liver Physiology
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
01:21Hepatic Portal System
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is...
01:24Chronic Kidney Disease II: Clinical Manifestations