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Is it possible to stage schizophrenia? A systematic review
Clara Martínez-Cao1,2,3, Lorena de la Fuente-Tomás1,2,3,4, Ainoa García-Fernández1,2,3
1Department of Psychiatry, Universidad de Oviedo, Oviedo, Spain.
Translational Psychiatry
|May 11, 2022
Summary
Clinical staging models for schizophrenia can be developed, but current versions have limitations. Future research should focus on empirical validation and incorporating biomarkers and patient perspectives for more accurate schizophrenia staging.
Area of Science:
- Psychiatry
- Clinical Psychology
- Neuroscience
Background:
- Schizophrenia staging models aim to define disease progression.
- Existing models vary in complexity and components.
- This study critically reviews proposed staging models and supporting empirical data.
Approach:
- Systematic literature review adhering to PRISMA guidelines.
- Searched PubMed and reference lists for relevant studies.
- Included 20 studies meeting specific inclusion criteria for schizophrenia staging models.
Key Points:
- Identified multiple clinical staging models for schizophrenia.
- Models often include neuroimaging, functioning, and psychopathology.
- Few models incorporate objective biomarkers or patient viewpoints.
- Limited psychometric testing and small sample sizes affect model validation.
- Some studies propose stage-specific therapeutic interventions.
Conclusions:
- Schizophrenia can be staged, but current models require improvement.
- Enhanced empirical validation is necessary.
- Inclusion of specific biomarkers and broader life area measures will improve model validity.
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