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Updated: Sep 23, 2025

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Highly efficient one-step microwave-assisted synthesis of structurally diverse bis-substituted α-amino acid derived
Marcin Konopka1,2, Grzegorz Markiewicz1,2, Artur R Stefankiewicz1,2
1Faculty of Chemistry, Adam Mickiewicz University Umultowska 89b 61-614 Poznań Poland ars@amu.edu.pl.
Abstract:
We report herein a facile and widely applicable microwave-assisted protocol for the synthesis of symmetrical diimides based on three structurally distinct aromatic dianhydrides: pyromellitic (PMA), biphenyl-tetracarboxylic acid (BPDA) and benzophenone-tetracarboxylic (BTDA) and five natural amino acids (Phe, Tyr, Ile, Lys, Cys). Fifteen symmetrical diimides with different structural characteristics containing a variety of functional groups can be produced with high yields and on a large scale.
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