Related Experiment Video
Updated: Sep 23, 2025
04:01
Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma
Published on: September 15, 2023
968
Synchronous Parathyroid Carcinoma and Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features
Ahmed Alajaimi1, Noor Altooq1, Nisha Chandran2
1College of Medicine & Medical Science, Arabian Gulf University, Manama, BHR.
Cureus
|May 13, 2022
Summary
This case report details an extremely rare instance of simultaneous parathyroid carcinoma and noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) in a middle-aged woman. The patient presented with severe hypercalcemia and fractures, highlighting the aggressive nature of parathyroid cancer.
Area of Science:
- Endocrinology
- Oncology
- Pathology
Background:
- Parathyroid carcinoma is a rare endocrine malignancy causing primary hyperparathyroidism, often presenting with severe hypercalcemia and elevated parathyroid hormone (PTH).
- Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is an uncommon variant of papillary thyroid cancer.
Observation:
- A middle-aged woman presented with multiple fractures and neck swelling, initially suspected as thyroid carcinoma.
- Investigations for primary hyperparathyroidism and hypercalcemia revealed a hyperfunctioning right parathyroid tumor.
Findings:
- Histopathological examination confirmed the coexistence of parathyroid carcinoma and NIFTP.
- The patient underwent successful right parathyroidectomy and total thyroidectomy.
Implications:
- This case underscores the extreme rarity of synchronous parathyroid cancer and thyroid neoplasms.
- Highlights the importance of comprehensive endocrine and oncologic evaluation in patients with complex presentations of hyperparathyroidism and neck masses.
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