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Updated: Sep 23, 2025
MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent
Published on: September 3, 2013
Novel oligopeptide nanoprobe for targeted cancer cell imaging
Wen-Qiang Ding1, Si-Yong Qin1, Yin-Jia Cheng1
1College of Chemistry and Materials Science, South-Central University for Nationalities Wuhan 430074 P. R. China sy-qin@mail.scuec.edu.cn aizhang@scuec.edu.cn.
Abstract:
Here we designed and constructed a tryptophan-phenylalanine-phenylalanine-tryptophan (WFFW) tetrapeptide, which generated photostable and tunable fluorescence emission signals from 340 nm to 500 nm. The WFFW tetrapeptide could self-assemble into a spherical nanostructure with enhanced fluorescence intensity. Driven by π-π stacking and hydrogen bond interaction, WFFW co-assembled with arginine-glycine-aspartic acid (RGD) modified WFFW to form a cancer-targeted fluorescent nanoprobe, which could selectively image the cancer cells.
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